元件指南
VectorBuilder提供了许多常用的载体元件,可供用户在设计载体时进行选择。下表按类型提供了这些常用元件的详细信息。
Stimulatory Domain
姓名 | 描述 | Application Notes | References | 序列 |
---|---|---|---|---|
CD3zeta | Intracellular domain of the T cell receptor-CD3ζ chain | Acts as a stimulatory molecule for activating T cell-mediated immune response. | Cell. 64:891 (1991); Nat Rev Immunol. 2:512 (2002); WO2014055771A1 | View |
Costimulatory Domain
姓名 | 描述 | Application Notes | References | 序列 |
---|---|---|---|---|
CD28 | CD28 intracellular costimulatory domain | Improves overall survival, proliferation and persistence of activated CAR-T cells. | Nat Biotechnol. 20:70 (2002); J Immunother. 32:689 (2009); WO2014055771A1 | View |
4-1BB | 4-1BB intracellular costimulatory domain | Improves overall survival, proliferation and persistence of activated CAR-T cells; further enhances cytotoxicity and durability when used in combination with CD28. | Leukemia. 18:676 (2004); Mol Ther. 17:1453 (2009); EP2904106A2 | View |