元件指南

VectorBuilder提供了许多常用的载体元件，可供用户在设计载体时进行选择。下表按类型提供了这些常用元件的详细信息。

姓名	描述	Application Notes	References	序列
CD3zeta	Intracellular domain of the T cell receptor-CD3ζ chain	Acts as a stimulatory molecule for activating T cell-mediated immune response.	Cell. 64:891 (1991); Nat Rev Immunol. 2:512 (2002); WO2014055771A1	View

姓名	描述	Application Notes	References	序列
CD28	CD28 intracellular costimulatory domain	Improves overall survival, proliferation and persistence of activated CAR-T cells.	Nat Biotechnol. 20:70 (2002); J Immunother. 32:689 (2009); WO2014055771A1	View
4-1BB	4-1BB intracellular costimulatory domain	Improves overall survival, proliferation and persistence of activated CAR-T cells; further enhances cytotoxicity and durability when used in combination with CD28.	Leukemia. 18:676 (2004); Mol Ther. 17:1453 (2009); EP2904106A2	View