Human RB1常用载体

Gene Information

  • Offical Gene Symbol RB1
  • Species Human (Homo sapiens)
  • Offical Full Name RB transcriptional corepressor 1
  • 别名 OSRC; PPP1R130; RB; p105-Rb; pRb; pp110
  • Other Desigations retinoblastoma-associated protein; GOS563 exon 17 substitution mutation causes premature stop; exon 17 tumor GOS561 substitution mutation causes premature stop; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; retinoblastoma 1; retinoblastoma suspectibility protein
  • NCBI基因ID 5925
  • 载体基本信息
    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
  • NCBI  | OMIM  | HGNC  | Ensembl

常用载体产品 (These vectors are available immediately)

Gene Expression Vectors
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
哺乳动物shRNA干扰载体
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
载体名称 载体类型 Knockdown Score
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