HUMAN MTOR

Human MTOR常用载体

基因信息

  • 基因符号MTOR
  • 物种 Human (Homo sapiens)
  • 基因全称mechanistic target of rapamycin kinase
  • 别名FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS
  • 其他描述serine/threonine-protein kinase mTOR; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein 1; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; rapamycin target protein 1
  • 载体基本信息
    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020] Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
  • NCBI基因ID2475
  • RefSeq转录本
  • RefSeq蛋白
  • 外部链接NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View
  • 查看基因编码

常用载体产品(该类载体有库存现货)

Gene Expression Vectors
该种预制载体通过载体家的骨架制备,采用广泛表达启动子驱动您的目标基因ORF表达。载体标签(如EGFP)已被添加到载体骨架。
哺乳动物shRNA干扰载体
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
载体名称载体类型 Knockdown Score 标记基因价格
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