HUMAN HLA-B

Human HLA-B常用载体

Gene Information

  • Offical Gene Symbol HLA-B
  • Species Human (Homo sapiens)
  • Offical Full Name major histocompatibility complex, class I, B
  • 别名 AS; B-4901; HLAB
  • Other Desigations major histocompatibility complex, class I, B; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, B alpha chain; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC class 1 antigen; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I molecule; leukocyte antigen class I-B
  • 载体基本信息
    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
  • NCBI基因ID 3106
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

常用载体产品

Gene Expression Vectors
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
哺乳动物shRNA干扰载体
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
载体名称 载体类型 Knockdown Score Marker 价格
{[ item.alias ]} {[ item.vector_type ]} {[ item.vector_type | boatFixI18nName: 'vectorSystem' | translate ]} {[ item.intrinsic_score ]} {[ item.marker || '-' ]} ¥{[ item.price || '' ]}
查看载体 

Can’t find desired vectors above? Use options below to obtain custom vectors.

设计我的载体

使用此选项设计载体并购买质粒构建及相应病毒包装服务

您可以在这里申请克隆和病毒包装的载体服务。

发送设计咨询

使用此选项让我们的专家免费为您设计载体,您也可以购买以下服务:

您可以在这里提交其他服务咨询,包括:

  • 病毒包装
  • CRISPR打靶
  • BAC 修饰
  • 文库构建
  • 质粒抽提
  • 体外转录
  • 诱导突变
  • 更多...