HUMAN CDKN2A

Human CDKN2A常用载体

基因信息

  • 基因符号CDKN2A
  • 物种 Human (Homo sapiens)
  • 基因全称cyclin dependent kinase inhibitor 2A
  • 别名ARF; CAI2; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16
  • 其他描述cyclin-dependent kinase inhibitor 2A; CDK4 inhibitor p16-INK4; CDKN2A/ARF Intron 2 lncRNA; alternative reading frame; cell cycle negative regulator beta; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); inhibitor of cdk4 A; multiple tumor suppressor 1; multiple tumour suppressor 1
  • 载体基本信息
    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
  • NCBI基因ID1029
  • RefSeq转录本
  • RefSeq蛋白
  • 外部链接NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View
  • 查看基因编码

常用载体产品(该类载体有库存现货)

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该种预制载体通过载体家的骨架制备,采用广泛表达启动子驱动您的目标基因ORF表达。载体标签(如EGFP)已被添加到载体骨架。
哺乳动物shRNA干扰载体
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
载体名称载体类型 Knockdown Score 标记基因价格
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