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Protein involved in Alzheimer's disease tau neurotoxicity identified
Latest Discovery
Protein involved in Alzheimer's disease tau neurotoxicity identified
Alzheimer's disease is the most common type of dementia and affects ~55 million people worldwide. Aggregation of tau is a defining feature of Alzheimer’s disease. Recently, researchers at the Indiana University School of Medicine identified Bassoon,...
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Gene therapy rescues metabolic function in lipodystrophy
Interesting Story
Gene therapy rescues metabolic function in lipodystrophy
Gene therapy is emerging as a promising candidate to treat a wide range of metabolic disorders. Recently, Dr. George Mcilroy and his team at the University of Aberdeen Rowett Institute and Cardiovascular and Diabetes Centre demonstrated the efficacy...
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Novel oncogenic fusion discovered and classified in pheochromocytoma
Research Trend
Novel oncogenic fusion discovered and classified in pheochromocytoma
Pheochromocytoma is a rare tumor that develops in the adrenal glands. To discover novel driver events of the disease, Dr. Patricia Dahia and her team at the University of Texas San Antonio Division of Hematology and Medical Oncology conducted whole...
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Single dose of off-the-shelf gene therapy boosts the immune system to fight cancer
Interesting Story
Single dose of off-the-shelf gene therapy boosts the immune system to fight cancer
One of the major challenges in the clinic for the treatment of various diseases is the ability to consistently deliver therapeutics at efficacious levels. Recently, researchers in the Division of Hematology and Oncology at Nationwide Children’s Hos...
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Gold labeled antibody fragments provide insight into the senses
Research Trend
Gold labeled antibody fragments provide insight into the senses
Stereocilia are important structures found in the inner ear that are involved in hearing and balance. Recently, scientists at the Vollum Institute at the Oregon Health and Science University were able to provide insight into the structure and confo...
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Molecular barcodes offer insight into cancer
Interesting Story
Molecular barcodes offer insight into cancer
New advances in molecular barcoding offer exciting possibilities, especially in cancer research. Over the years, molecular barcoding involved generating specific nucleic acids or proteins within cells to trace lineages across generations to observe...
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SARS-CoV-2 variants: Human antibody-mediated immunity or Harry Houdini?
Breaking News
SARS-CoV-2 variants: Human antibody-mediated immunity or Harry Houdini?
The pandemic COVID-19 has caused over 2 million deaths globally with the numbers increasing at an alarming rate. A monumental worldwide vaccination program is being rolled out with several companies including AstraZeneca/Oxford University, Pfizer/Bi...
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A real breakthrough for Parkinson’s disease?
Latest Discovery
A real breakthrough for Parkinson’s disease?
One of the greatest barriers to treating neural degeneration and neural tissue injury is the fact that neurons do not proliferate, and there are only a few areas of the brain that exhibit neurogenesis. It is possible to convert one somatic cell type...
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A powerful mouse model for studying Covid-19
Research Trend
A powerful mouse model for studying Covid-19
We have all been engulfed by the current SARS-CoV-2 pandemic with the lives of millions affected. To date, COVID-19 has resulted in almost 8 million confirmed cases with over 400,000 deaths. Considerable effort and money have been invested in trying...
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Coronavirus – How it began
Breaking News
Coronavirus – How it began
During the beginning of this year, a novel coronavirus disease — termed Covid-19 by the WHO — was identified as being responsible for a sudden increase in cases of pneumonia in hospitalized patients. We have seen this rapidly escalate into a global...
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De-arming CRISPR/Cas9 to increase knock-in efficiency
Latest Discovery
De-arming CRISPR/Cas9 to increase knock-in efficiency
The ability to knock in (KI) DNA sequences via homologous recombination (HR) to generate knockout (KO) mice was first demonstrated 30 years ago by Mario R. Capecchi, Martin J. Evans and Oliver Smithies (1,2). In recent years, CRISPR/Cas9 has revolut...
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A new scar reduction role for engineered T cells
Research Trend
A new scar reduction role for engineered T cells
Cardiovascular diseases (CVDs) are the number one cause of death globally, responsible for 31% of all human mortalities. This is in part due to lifestyle but also because the human heart is incapable of functional regeneration following injury or on...
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The painless people
Interesting Story
The painless people
Wouldn’t it be nice if we felt no pain? Although lacking the ability to feel pain sounds tempting, considering we could have simply moved on with our lives without going through the hassle of tending to our injuries, the consequences of being painles...
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From fibroblast to blastocyst: the magic ingredients
Latest Discovery
From fibroblast to blastocyst: the magic ingredients
When the lab of Shinya Yamanaka revealed that viral introduction of Oct3/4, Sox2, Klf4 and c-Myc (OSKM) into adult skin cells could transform them into induced pluripotent stem cells (iPSCs), the world quickly took notice at the prospect of using iP...
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CRISPRing our cellular roots
Research Trend
CRISPRing our cellular roots
The remarkable process by which a single totipotent zygote develops into the approximately 37 trillion cells in a human body is orchestrated by a highly controlled sequence of signaling events resulting in a multitude of differentiated cell types. Th...
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