HUMAN LOC110806262

Human LOC110806262常用载体

Gene Information

  • Offical Gene Symbol LOC110806262
  • Species Human (Homo sapiens)
  • Offical Full Name -
  • 别名 -
  • Other Desigations 5-HTT promoter; 5-HTTLPR promoter polymorphism region; SLC6A4 promoter; serotonin transporter gene promoter
  • 载体基本信息
    This genomic sequence represents the 5\' regulatory region of the solute carrier family 6 member 4 (SLC6A4) gene on chromosome 17. It includes the gene promoter and a polymorphic region known as 5-HTTLPR, which is located approximately 1 kb upstream of the major transcription start site. The polymorphic region is composed of 16 tandemly-repeated units in the long (L) allele, where each repeat unit is 20-23 bps in length. Deletion of repeat units 6-8 results in a short (S) allele. Single nucleotide polymorphisms, including rs25531 and rs25532, have also been identified in this region. The 5-HTTLPR region has both positive- and negative-acting cis-regulatory components in SLC6A4 promoter activity assays, and the L and S alleles also display allele-dependent promoter activity. Due to the role of the SLC6A4 gene in serotonin reuptake, a large number of studies have associated the 5-HTTLPR, rs25531 and rs25532 polymorphisms with a variety of mood, behavioral and stress-related psychopathologies. However, these associations are complex and may be population-dependent, and/or related to epigenetic processes or other known polymorphisms, including the STin2 variable number tandem repeat (VNTR) that overlaps an enhancer element in an SLC6A4 intron. [provided by RefSeq, Aug 2017]
  • NCBI基因ID 110806262
  • External Links NCBI

常用载体产品

Gene Expression Vectors
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
哺乳动物shRNA干扰载体
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
载体名称 载体类型 Knockdown Score Marker 价格
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