HUMAN MMP2

Human MMP2常用载体

基因信息

  • 基因符号MMP2
  • 物种 Human (Homo sapiens)
  • 基因全称matrix metallopeptidase 2
  • 别名CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
  • 其他描述72 kDa type IV collagenase; collagenase type IV-A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; neutrophil gelatinase
  • 载体基本信息
    This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
  • NCBI基因ID4313
  • RefSeq转录本
  • RefSeq蛋白
  • 外部链接NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View
  • 查看基因编码

常用载体产品(该类载体有库存现货)

Gene Expression Vectors
该种预制载体通过载体家的骨架制备,采用广泛表达启动子驱动您的目标基因ORF表达。载体标签(如EGFP)已被添加到载体骨架。
哺乳动物shRNA干扰载体
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
载体名称载体类型 Knockdown Score 标记基因价格
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