HUMAN AR

Human AR常用载体

Gene Information

  • Offical Gene Symbol AR
  • Species Human (Homo sapiens)
  • Offical Full Name androgen receptor
  • 别名 AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM
  • Other Desigations androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4
  • 载体基本信息
    The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy\'s disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
  • NCBI基因ID 367
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

常用载体产品

Gene Expression Vectors
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
哺乳动物shRNA干扰载体
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
载体名称 载体类型 Knockdown Score Marker 价格
{[ item.alias ]} {[ item.vector_type ]} {[ item.vector_type | boatFixI18nName: 'vectorSystem' | translate ]} {[ item.intrinsic_score ]} {[ item.marker || '-' ]} ¥{[ item.price || '' ]}
查看载体 

Can’t find desired vectors above? Use options below to obtain custom vectors.

设计我的载体

使用此选项设计载体并购买质粒构建及相应病毒包装服务

您可以在这里申请克隆和病毒包装的载体服务。

发送设计咨询

使用此选项让我们的专家免费为您设计载体,您也可以购买以下服务:

您可以在这里提交其他服务咨询,包括:

  • 病毒包装
  • CRISPR打靶
  • BAC 修饰
  • 文库构建
  • 质粒抽提
  • 体外转录
  • 诱导突变
  • 更多...