载体基本信息The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that shares features in common with bird and fish antizyme 1. Like vertebrate antizyme 1 mRNA, this antizyme mRNA contains multiple potential in-frame translation initiation sites. [provided by RefSeq, Feb 2015]